The Edinburgh Malaria Project develops and applies mathematical models to evaluate the long-term impact of malaria interventions, particularly vaccines such as RTS,S, R21, and RH5.1, as well as seasonal malaria chemoprevention (SMC). The project aims to predict clinical malaria cases, severe malaria episodes, and malaria-related deaths averted by these interventions over the lifetime of vaccinated cohorts, accounting for factors like waning vaccine efficacy, rebound effects due to inhibited natural immunity development, and varying transmission intensities.